Jastrzebska M, Chełstowski K, Torbus-Lisiecka B, Pieczul-Mróz J, Wesołowska T, Wira D
Zakład Biochemii Klinicznej i Diagnostyki Laboratoryjnej Pomorskiej Akademii Medycznej, Szczecinie.
Kardiol Pol. 1992 Sep;37(9):136-41.
The authors presented the effect of unfractionated heparin on platelet aggregation and fibrinolysis. The studies have been performed in the control group and with primary hypertriglyceridemia as well as in patients after myocardial infarction. Adrenaline and ADP induced platelet aggregation was examined in plasma rich platelets; fibrinolysis was estimated in euglobulin test. These parameters have been determined before and after (10, 20, 60, 240, 360 min.) intravenous injection of 50 units heparin per kg body weight. We have observed, that heparin increased also platelet aggregation and inhibited fibrinolytic activity in persons with primary hypertriglyceridemia particularly and after myocardial infarction. Correlation was found between investigated parameters and products of heparin lipolytic activity, especially with level of free fatty acids.
作者介绍了普通肝素对血小板聚集和纤维蛋白溶解的影响。研究在对照组、原发性高甘油三酯血症患者以及心肌梗死后患者中进行。在富含血小板的血浆中检测肾上腺素和二磷酸腺苷诱导的血小板聚集；在优球蛋白试验中评估纤维蛋白溶解。在静脉注射每公斤体重50单位肝素之前和之后（10、20、60、240、360分钟）测定这些参数。我们观察到，肝素尤其在原发性高甘油三酯血症患者以及心肌梗死后患者中也增加了血小板聚集并抑制了纤维蛋白溶解活性。在所研究的参数与肝素脂解活性产物之间发现了相关性，尤其是与游离脂肪酸水平相关。
