Lehmann M, Hasler K, Hasenfuss G, Holubarsch C, Staiger A, Kasper W, Keul J
Z Kardiol. 1985 Oct;74(10):611-7.
Induced in vitro platelet aggregation (adrenaline and collagen) and serum lipid levels were investigated in 21 postinfarction patients, in 11 of these patients subsequent to therapy with 46 +/- 14 mg nifedipine per os daily for one week and in 21 untrained, 16 endurance-trained, and 17 non-endurance-trained healthy male control subjects. Plasma catecholamine levels at rest (patients) and oxygen uptake capacity (control subjects) were determined in subgroups. Mean platelet aggregation was increased in patients (p less than 0.05) and was decreased both in endurance-trained subjects (p less than 0.05) and in the group of 11 patients subsequent to therapy with nifedipine (p less than 0.01), but platelet aggregation was slightly higher in non-endurance-trained individuals. Adrenaline-induced platelet aggregation correlated positively with collagen-induced aggregation (r = 0.72), with LDL-cholesterol fraction (r = 0.51) and negatively with oxygen uptake capacity (r = -0.49). Patients with increased LDL-cholesterol levels also showed increased plasma catecholamine levels (r = 0.49 and r = 0.43). Low aerobic capacity (oxygen uptake capacity), high LDL-cholesterol levels and plasma catecholamine concentrations indicate an increased induced platelet sensitivity in vitro.
对21例心肌梗死后患者、21名未经训练的健康男性对照者、16名耐力训练的健康男性对照者和17名非耐力训练的健康男性对照者，研究了体外诱导的血小板聚集（肾上腺素和胶原）及血脂水平。对各亚组测定了静息时的血浆儿茶酚胺水平（患者）和摄氧能力（对照者）。患者的平均血小板聚集增加（p<0.05），耐力训练的受试者（p<0.05）和11例接受硝苯地平每日46±14mg口服治疗一周后的患者组（p<0.01）的血小板聚集均降低，但非耐力训练个体的血小板聚集略高。肾上腺素诱导的血小板聚集与胶原诱导的聚集呈正相关（r = 0.72），与低密度脂蛋白胆固醇组分呈正相关（r = 0.51），与摄氧能力呈负相关（r = -0.49）。低密度脂蛋白胆固醇水平升高的患者血浆儿茶酚胺水平也升高（r = 0.49和r = 0.43）。低有氧能力（摄氧能力）、高低密度脂蛋白胆固醇水平和血浆儿茶酚胺浓度表明体外诱导的血小板敏感性增加。
