BINGHAM R
Calif Med. 1951 Feb;74(2):108-10.
Systemic penicillin therapy plus refrigeration at the site of the lesion, with operation if necessary, was used in the treatment of chronic osteomyelitis. Nine patients with disease of long standing were treated. For three, bed rest, chemotherapy and refrigeration were sufficient. Surgical treatment in addition was carried out in six cases. Operations consisted of unroofing the abscess cavity, multiple drilling for sievelike perforation of the abscessed bone, and primary suture of the incision. Solutions of penicillin, 500 to 1,000 units per cubic centimeter, were used for local irrigation at the time of closure. In all cases the lesions healed and there was no recurrence within a period of two years. The period of hospitalization did not exceed 14 days in any case.Refrigeration of the infected area before and after operation reduced pain, swelling, infection and toxemia.
全身青霉素治疗加病变部位冷藏，必要时手术，用于治疗慢性骨髓炎。对9例病程较长的患者进行了治疗。其中3例，卧床休息、化疗和冷藏就足够了。另外6例进行了手术治疗。手术包括脓肿腔去顶、对脓肿骨进行多处钻孔以形成筛状穿孔，以及切口一期缝合。缝合时使用每立方厘米含500至1000单位青霉素的溶液进行局部冲洗。所有病例的病变均愈合，两年内无复发。在任何情况下，住院时间均不超过14天。手术前后对感染区域进行冷藏可减轻疼痛、肿胀、感染和毒血症。
