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[迷走神经切断术后大鼠小肠中过氧化氢酶各种特性的变化]

[Change in various properties of catalase in the small intestine of rats after vagotomy].

作者信息

Tsibulevskiĭ A Iu, Titov V Iu, Petrenko Iu M

出版信息

Patol Fiziol Eksp Ter. 1992 May-Jun(3):44-6.

PMID:1480425
Abstract

To evaluate the antioxidative system of the small intestine in disturbed parasympathetic innervation, the authors studied the activity of catalase, its resistance to substrate inactivation (catalytic capacity) and reduction potential (reduction of Fe3+ to Fe2+) in the enteric homogenate in different periods (on day 14 and 30) after bilateral subdiaphragmatic truncal vagotomy. Vagotomy did not change catalase activity but was attended by an increase of catalase catalytic capacity and reduction potential. It is suggested that the discovered changes of the studied parameters are manifestations of responses of the antioxidative protective system of the small intestine to the activation of lipid peroxidation.

摘要

为评估副交感神经支配紊乱时小肠的抗氧化系统,作者研究了双侧膈下迷走神经干切断术后不同时期(第14天和30天)肠匀浆中过氧化氢酶的活性、其对底物失活的抗性(催化能力)和还原电位(Fe3+还原为Fe2+)。迷走神经切断术并未改变过氧化氢酶活性,但伴随着过氧化氢酶催化能力和还原电位的增加。提示所研究参数的这些变化是小肠抗氧化保护系统对脂质过氧化激活的反应表现。

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