Varga G, Solomon T E, Reidelberger R D, Wood J, Papp M
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
Acta Med Hung. 1987;44(1):43-54.
The effect of chronic subdiaphragmatic truncal vagotomy was investigated on body weight gain, food intake pattern, and also on intestinal and pancreatic growth, in adult rats. Two sham-operated groups, the one fed ad libitum, the other pair-fed with the vagotomized rats, served as controls. Body weight of vagotomized rats decreased in the first 5 postoperative days, due to hypophagia. Then, body weight increased as food intake reached the presurgery level. The rats were killed after 34 days of vagotomy. A moderate pancreatic and intestinal hypertrophy was observed in the vagotomized rats, while the tissue weight of and the DNA and protein contents in the colon and the oxyntic and antral areas of the stomach did not change compared to controls. The mechanism of the intestinal and pancreatic hypertrophy is unknown; several humoral and nervous factors may be involved in it.
研究了成年大鼠慢性膈下迷走神经干切断术对体重增加、食物摄入模式以及肠道和胰腺生长的影响。两个假手术组，一组自由进食，另一组与迷走神经切断术大鼠配对喂食，作为对照。迷走神经切断术大鼠的体重在术后第1天至第5天因摄食减少而下降。然后，随着食物摄入量达到术前水平，体重增加。迷走神经切断术后34天处死大鼠。观察到迷走神经切断术大鼠出现中度胰腺和肠道肥大，而与对照组相比，结肠以及胃的泌酸区和胃窦区的组织重量、DNA和蛋白质含量没有变化。肠道和胰腺肥大的机制尚不清楚；可能涉及多种体液和神经因素。
