Poppema S
Department of Laboratory Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada.
Semin Diagn Pathol. 1992 Nov;9(4):257-64.
Nodular lymphocyte-predominance Hodgkin's disease (NLPHD) has emerged as a distinct entity. It has a precursor lesion, known as follicular hyperplasia with progressively transformed germinal centers (PTGC), and a late stage consisting of transformation to a large cell lymphoma. All cellular components of NLPHD are derived from follicles, but so far no clonal population has been identified.
结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHD）已成为一种独特的实体。它有一个前驱病变，称为生发中心进行性转化的滤泡性增生（PTGC），以及一个晚期阶段，即转化为大细胞淋巴瘤。NLPHD的所有细胞成分均来源于滤泡，但迄今为止尚未发现克隆性群体。
