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[乙型肝炎病毒患者肝组织中乙肝病毒标志物及铁代谢产物的形态学特征]

[Morphologic characteristics of HBV markers and products of iron metabolism in liver tissue in patients with hepatitis B virus].

作者信息

Dimitrijević J, Bojanić N, Skaro-Milić A, Mijusković P, Ilić S, Nozić D

机构信息

Vojnomedicinska akademija, Institut za patologiju i sudsku medicinu.

出版信息

Vojnosanit Pregl. 1992 Sep-Oct;49(5):477-83.

PMID:1481464
Abstract

In the histomorphologic analysis of 126 liver biopsies with hepatitis B virus (HBV) infection the authors have met some difficulties in the interpretation of findings of three biopsies which showed the presence of hemosiderine and ferritin deposits in hepatocytes. The lack of cells with the appearance of "ground glass", that is, ground glass hepatocytes which are one of the important features of HBV infection and aberration from the standard features in some histochemical stainings are noticed in all three biopsies. Since only few authors have noticed the same problem, it is possible that these results open new ways in the study of pathogenesis of HBV infection in the liver and its relationship with iron metabolism.

摘要

在对126例乙型肝炎病毒(HBV)感染患者的肝脏活检组织进行组织形态学分析时,作者在解读3例活检结果时遇到了一些困难,这3例活检显示肝细胞内存在含铁血黄素和铁蛋白沉积。在所有3例活检中均未发现呈现“毛玻璃样”外观的细胞,即毛玻璃样肝细胞,而毛玻璃样肝细胞是HBV感染的重要特征之一,并且在某些组织化学染色中出现了与标准特征不符的情况。由于只有少数作者注意到了同样的问题,所以这些结果有可能为研究肝脏中HBV感染的发病机制及其与铁代谢的关系开辟新的途径。

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