Merimsky O, Reider-Groswasser I, Wigler N, Chaitchik S
Department of Oncology, Ichilov Hospital, Sourasky Medical Center, Tel-Aviv University, Israel.
Acta Neurol Scand. 1992 Nov;86(5):521-5. doi: 10.1111/j.1600-0404.1992.tb05136.x.
Acute encephalopathy following treatment with ifosfamide and mesna was observed in 5 (4 women and 1 men) of 28 patients (17.8%), with advanced sarcoma, lymphoma or ovarian carcinoma. This appeared within 2 to 7 days following the first dose of ifosfamide treatment, and included mental status changes, urinary incontinence, weakness, seizure activity, altered consciousness and psychiatric manifestations. Three cases were fatal, while two patients recovered completely. Brain CT and morphometric studies were normal in all the patients. Associated findings were myelosuppression, renal failure and electrolyte alterations.
在28例患有晚期肉瘤、淋巴瘤或卵巢癌的患者中，有5例（4名女性和1名男性，占17.8%）在接受异环磷酰胺和美司钠治疗后出现急性脑病。这在首次给予异环磷酰胺治疗后的2至7天内出现，症状包括精神状态改变、尿失禁、虚弱、癫痫活动、意识改变和精神症状。3例死亡，2例患者完全康复。所有患者的脑部CT和形态学研究均正常。相关表现为骨髓抑制、肾衰竭和电解质紊乱。
