Karlinsky H, Berg J M, Lennox A, Ray P N, St George-Hyslop P, Farrer L A, Percy M E, Andrews D F, Atack E A
Geriatric Psychiatry Service, Queen Elizabeth Hospital, Toronto, Ontario, Canada.
Am J Med Genet. 1992 Nov 15;44(5):591-7. doi: 10.1002/ajmg.1320440512.
Probable Alzheimer disease (AD) is described in 79-year-old male twins with monozygosity confirmed by DNA examination. The first twin to be affected began to show signs of intellectual deterioration at age 70. In the other, onset was at age 72. Four of their living sibs (current age range = 75-92) are also suspected to have AD. The possible roles of genetic and environmental factors in the development of AD in this sibship are discussed.
通过DNA检测确认的79岁同卵双胞胎男性被诊断患有可能的阿尔茨海默病（AD）。首先发病的双胞胎在70岁时开始出现智力衰退迹象。另一个则在72岁发病。他们在世的4个兄弟姐妹（当前年龄范围为75 - 92岁）也被怀疑患有AD。本文讨论了遗传和环境因素在这一家族中AD发病过程中可能起到的作用。
