Zubenko G S, Ferrell R E
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania.
Am J Med Genet. 1988 Feb;29(2):431-6. doi: 10.1002/ajmg.1320290227.
This report describes monozygotic twins who were concordant for probable Alzheimer disease, as defined by currently-accepted clinical criteria. Monozygosity was established by blood typing. Their ages of symptomatic onset were 57 and 66 yr, and the times from onset to institutionalization were 8 and 2 yr, respectively. These results suggest that age at onset and rate of progression are clinical features that can be affected by random processes or exposure to environmental factors. The platelet membrane fluidity of both twins was abnormally increased, and the respective values were identical within experimental limits. This result is consistent with published data suggesting that increased platelet membrane fluidity is associated with a clinically distinct subtype of Alzheimer disease and that this platelet membrane characteristic may be genetically determined.
本报告描述了一对同卵双胞胎，根据目前公认的临床标准，他们均患有可能的阿尔茨海默病。通过血型鉴定确定为同卵双胞胎。他们出现症状的年龄分别为57岁和66岁，从发病到住院的时间分别为8年和2年。这些结果表明，发病年龄和进展速度是可能受随机过程或环境因素影响的临床特征。这对双胞胎的血小板膜流动性均异常增加，且在实验范围内各自的值相同。这一结果与已发表的数据一致，这些数据表明血小板膜流动性增加与阿尔茨海默病一种临床上独特的亚型相关，并且这种血小板膜特征可能由基因决定。
