Burattini R, Montanari L, Mulligan L J, Cannon M S, Gross D R
Department of Electronics and Automatica, University of Ancona, Italy.
Am J Physiol. 1992 Dec;263(6 Pt 2):H1919-26. doi: 10.1152/ajpheart.1992.263.6.H1919.
Measurements of pulsatile pressure and flow at the input of the left and right carotid arteries and a new lumped parameter model were used to quantify changes in the overall dynamic mechanical properties of the carotid circulation between five control diet-fed pigs and five pigs fed a hyperlipidemic diet for 16 wk. The model represents the portion of the circulation supplied by either the left or the right carotid artery and is characterized by five parameters: peripheral resistance (Rp), an overall inertance (L), and an overall frequency-dependent compliance constituted by a capacitor C (static compliance) in series with a Maxwell section, i.e., a capacitor Cd, in parallel with a resistor Rd. Rp was calculated as the ratio between mean pressure (P) and mean flow (Q). The other four parameters were estimated by fitting measured to model predicted flows. The average static compliance was reduced by 40% (P = 0.01) between normal (P = 62.0 +/- 4.3 mmHg) and hyperlipidemic diet-fed pigs (P = 62.7 +/- 4.7 mmHg). A significant reduction in the overall cross-sectional area was inferred from a 53% increase (P = 0.05) in L, whereas resistance vessel tone was unchanged as judged from estimates of Rp. No signs of occlusive disease were found in any of the animals.
通过测量5只喂食对照饮食的猪和5只喂食高脂饮食16周的猪的左右颈动脉输入端的脉动压力和流量，并采用一种新的集总参数模型，来量化颈动脉循环整体动态力学特性的变化。该模型代表由左或右颈动脉供应的循环部分，其特征由五个参数表示：外周阻力（Rp）、总惯性（L）以及由一个电容C（静态顺应性）与一个麦克斯韦部分串联构成的总频率依赖性顺应性，即一个电容Cd与一个电阻Rd并联。Rp计算为平均压力（P）与平均流量（Q）之比。其他四个参数通过将测量流量与模型预测流量拟合来估计。正常猪（P = 62.0 +/- 4.3 mmHg）和喂食高脂饮食的猪（P = 62.7 +/- 4.7 mmHg）之间的平均静态顺应性降低了40%（P = 0.01）。从L增加53%（P = 0.05）推断总横截面积显著减小，而根据Rp的估计判断阻力血管张力未改变。在任何动物中均未发现闭塞性疾病的迹象。
