Trostel K A, Osborn J W
Department of Veterinary Biology, University of Minnesota, St. Paul 55108.
Am J Physiol. 1992 Dec;263(6 Pt 2):R1265-70. doi: 10.1152/ajpregu.1992.263.6.R1265.
Previous studies have demonstrated that renal nerve activity has acute effects on renal function in rats with cervical spinal cord transection (CST). The present study tested the hypothesis that renal nerves chronically influence renal and cardiovascular function in CST rats. Three groups of conscious Sprague-Dawley rats were studied: renal denervated plus CST (RDNX + CST), sham RDNX plus CST (sham + CST), and sham RDNX plus sham CST (intact). CST or sham CST surgeries were performed 8 days after RDNX or sham RDNX. Sodium and water intakes were fixed by intravenous infusion. Mean arterial pressure (MAP) and plasma renin activity (PRA) were measured before and for 9 days after CST/sham CST. In addition, urine flow, urinary sodium excretion, and urine pH were measured in the two groups of CST rats. One day after CST, MAP decreased approximately 25 mmHg in both RDNX + CST and sham + CST groups. PRA had fallen approximately 50% 1 day after CST and was not different between CST groups. PRA remained depressed throughout the study. There were no differences between sham + CST and RDNX + CST rats in any of the renal or cardiovascular variables measured after CST. In summary, we found no evidence for a chronic effect of renal nerves on renal function or arterial pressure in CST rats.
先前的研究表明，肾神经活动对颈髓横断（CST）大鼠的肾功能有急性影响。本研究检验了肾神经长期影响CST大鼠的肾脏和心血管功能这一假说。研究了三组清醒的Sprague-Dawley大鼠：去肾神经加CST（RDNX + CST）、假去肾神经加CST（假手术 + CST）以及假去肾神经加假CST（完整组）。在去肾神经或假去肾神经8天后进行CST或假CST手术。通过静脉输注固定钠和水的摄入量。在CST/假CST之前及之后9天测量平均动脉压（MAP）和血浆肾素活性（PRA）。此外，在两组CST大鼠中测量尿流量、尿钠排泄和尿pH。CST后1天，RDNX + CST组和假手术 + CST组的MAP均下降约25 mmHg。CST后1天PRA下降约50%，且CST组之间无差异。在整个研究过程中PRA一直处于较低水平。CST后测量的任何肾脏或心血管变量在假手术 + CST组和RDNX + CST组之间均无差异。总之，我们没有发现肾神经对CST大鼠的肾功能或动脉压有长期影响的证据。
