Tsancheva M
Eksp Med Morfol. 1976;15(3):181-7.
The author examined the action of haloperidol and magetyl on the mitotic activity, blast transformation and karyotype of the lymphocytic cultures, obtained from the peripheral blood in vitro. The experiments were carried out on flymphycytes, obtained from ten healthy individuals. Nontreated cultures, obtained from the same cultures, were used as controls. The following concentrations were used: haloperidol--0.1 mkg/ml, 10 mkg/ml and 10.0 mkg/ml; mageptyl--2.0 mkg/ml, 10,0 mkg/ml and 50 mkg/ml. There was a significant inhibition of the mitotic and blast transformation index after using concentrations of 10.0 mkg/ml both of haloperidol and magentyl. Concentration of 50.0 mkg/ml was toxic for the lymphocytes, obtaine from all donors. Furthermore the two preparations did not induce genomic mutations. Polyploidia, established in the treated cultures, varied slightly from that of the nontreated cultures. There was a weak mutagenic activity of the two preparations at chromosomal level in a concentration of 10.0 mkg/ml.
作者研究了氟哌啶醇和马庚替酯对体外从外周血获得的淋巴细胞培养物的有丝分裂活性、胚细胞转化及核型的作用。实验用的淋巴细胞取自10名健康个体。取自相同培养物的未处理培养物用作对照。使用了以下浓度：氟哌啶醇——0.1微克/毫升、10微克/毫升和10.0微克/毫升；马庚替酯——2.0微克/毫升、10.0微克/毫升和50微克/毫升。使用10.0微克/毫升浓度的氟哌啶醇和马庚替酯后，有丝分裂和胚细胞转化指数均受到显著抑制。50.0微克/毫升的浓度对所有供体的淋巴细胞均有毒性。此外，这两种制剂均未诱导基因组突变。处理过的培养物中出现的多倍体与未处理培养物的多倍体略有不同。在10.0微克/毫升浓度时，这两种制剂在染色体水平有微弱的诱变活性。
