KARZON D T, BANG F B
J Exp Med. 1951 Mar;93(3):285-96. doi: 10.1084/jem.93.3.285.
Circulating antibody appeared in the convalescing NDV-infected chicken concomitantly with the disappearance of virus from the tissues. The antigenic response to the CG 179 and B strains was demonstrated to be approximately equal. The neutralization test in the embryo and the hemagglutination inhibition technique yielded parallel results in the measurement of antibody early in convalescence, but late in convalescence the hemagglutination inhibition titers were relatively lower. This disparity indicates the possible duality of the antibodies. There was a wide ratio between the neutralizing antibody titers found in the brain and in the serum after an asymptomatic infection with NDV. The antibody level in the brain appeared to be related to the extent of virus growth and damage in the central nervous system. It appeared likely that a major factor in determining the virulence of the CG 179 strain was the more rapid attainment in the central nervous system of high virus concentration which outstripped the defense mechanisms of the host.
在新城疫病毒（NDV）感染康复的鸡体内，循环抗体伴随病毒从组织中消失而出现。对CG 179株和B株的抗原反应显示大致相等。在恢复期早期，胚胎中和试验和血凝抑制技术在抗体测量中产生平行结果，但在恢复期后期，血凝抑制效价相对较低。这种差异表明抗体可能具有双重性。在无症状感染NDV后，在脑和血清中发现的中和抗体效价之间存在很大差异。脑中的抗体水平似乎与中枢神经系统中病毒生长和损伤的程度有关。看来决定CG 179株毒力的一个主要因素是在中枢神经系统中更快地达到高病毒浓度，这超过了宿主的防御机制。
