肝再生对喂食4-二甲基氨基偶氮苯的大鼠肿瘤形成的影响。
The effect of liver regeneration on tumor formation in rats fed 4-dimethylaminoazobenzene.
作者信息
GLINOS A D, BUCHER N L R, AUB J C
出版信息
J Exp Med. 1951 Apr 1;93(4):313-25. doi: 10.1084/jem.93.4.313.
Abstract
Partial hepatectomies were performed on five groups of rats which had been maintained on a diet containing 4-dimethylaminoazobenzene for various lengths of time. The effect of regeneration on the incidence of hepatic tumors was compared with that in similarly treated non-hepatectomized controls. Regeneration, and the time of exposure to the carcinogen as well, were relatively effective in accelerating the rate of appearance of tumors, although not markedly so. These factors were without effect on final total tumor formation. These findings support the concept that during chemical carcinogenesis tumor formation proceeds in stages.
摘要
对五组喂食含4-二甲基氨基偶氮苯不同时长的大鼠进行了部分肝切除术。将肝再生对肝肿瘤发生率的影响与同样处理的未进行肝切除的对照组进行了比较。肝再生以及接触致癌物的时间在加速肿瘤出现率方面相对有效，尽管效果不明显。这些因素对最终的肿瘤总形成没有影响。这些发现支持了化学致癌过程中肿瘤形成分阶段进行的概念。
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