Craddock V M, Frei J V
Br J Cancer. 1974 Dec;30(6):503-11. doi: 10.1038/bjc.1974.229.
A single treatment of adult animals with the potent carcinogen NMU was known to induce tumours in a wide variety of organs, with the notable exception of liver. Administration of NMU after partial hepatectomy gave rise to the first liver cell adenomata ever observed in rats due to this carcinogen. The tumours were induced when NMU was given during the period of increased DNA synthesis but not when given early in the pre-replicative period. Although tumours were induced in other organs, the incidence of these did not correlate with the timing of NMU administration. It is suggested that replication of damaged DNA may be a relevant event in carcinogenesis.
已知用强效致癌物NMU单次处理成年动物会在多种器官中诱发肿瘤，但肝脏是个显著例外。在部分肝切除术后给予NMU，首次在大鼠中诱发了由这种致癌物导致的肝细胞腺瘤。当在DNA合成增加期间给予NMU时会诱发肿瘤，但在复制前期早期给予则不会。尽管在其他器官中也诱发了肿瘤，但这些肿瘤的发生率与给予NMU的时间无关。有人提出，受损DNA的复制可能是致癌过程中的一个相关事件。
