• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

3,5-二苯基-1H-吡唑衍生物。X. 具有抗炎及其他活性的N-取代的1-(2-氨基丙基)-和1-(3-氨基-2-羟丙基)-3,5-二苯基-1H-吡唑

3,5-Diphenyl-1H-pyrazole derivatives. X. N-substituted 1-(2-aminopropyl)- and 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles with antiinflammatory and other activities.

作者信息

Bruno O, Ranise A, Bondavalli F, Schenone P, D'Amico M, Lampa E, Falzarano C, Rossi F

机构信息

Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.

出版信息

Farmaco. 1992 Oct;47(10):1235-48.

PMID:1482515
Abstract

The syntheses of 1-(2-hydroxypropyl)-3,5-diphenyl-1H-pyrazole 1 by reaction of 1-hydrazino-2-propanol with dibenzoylmethane and of N-substituted 1-(2-aminopropyl)-3,5-diphenyl-1H-pyrazoles 3 by reaction of primary and secondary amines with the tosylate of 1, as well as of N-substituted 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles 6 starting from 3,5-diphenyl-1H-pyrazole, are described. Some compounds 3 and 6 showed remarkable antiinflammatory activity in rats, as well as weak analgesic, antipyretic, antiarrhythmic, hypotensive activities in mice and rats and moderate platelet antiaggregating effects in vitro.

摘要

描述了通过1-肼基-2-丙醇与二苯甲酰甲烷反应合成1-(2-羟丙基)-3,5-二苯基-1H-吡唑1，通过伯胺和仲胺与1的对甲苯磺酸盐反应合成N-取代的1-(2-氨基丙基)-3,5-二苯基-1H-吡唑3，以及从3,5-二苯基-1H-吡唑出发合成N-取代的1-(3-氨基-2-羟丙基)-3,5-二苯基-1H-吡唑6。一些化合物3和6在大鼠中显示出显著的抗炎活性，在小鼠和大鼠中还具有微弱的镇痛、解热、抗心律失常、降压活性，在体外具有中等的血小板抗聚集作用。

相似文献

1
3,5-Diphenyl-1H-pyrazole derivatives. X. N-substituted 1-(2-aminopropyl)- and 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles with antiinflammatory and other activities.3,5-二苯基-1H-吡唑衍生物。X. 具有抗炎及其他活性的N-取代的1-(2-氨基丙基)-和1-(3-氨基-2-羟丙基)-3,5-二苯基-1H-吡唑
Farmaco. 1992 Oct;47(10):1235-48.
2
3,5-Diphenyl-1H-pyrazole derivatives. VI--Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities.3,5-二苯基-1H-吡唑衍生物。VI——1-(2-羟基-2-苯乙基)-3,5-二苯基-1H-吡唑的酯类和2-二烷基氨基乙基醚类以及具有镇静和血小板抗聚集活性的N,N-二取代-1-(2-氨基-2-苯乙基)-3,5-二苯基-1H-吡唑
Farmaco. 1990 May;45(5):511-26.
3
3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities.3,5-二苯基-1H-吡唑衍生物。VIII. N-取代的3-(4-羟基-3,5-二苯基-1H-吡唑-1-基)丙酰胺、丙胺及2-(4-羟基-3,5-二苯基-1H-吡唑-1-基)乙胺，具有抗血小板聚集、降压、抗心律失常及其他活性。
Farmaco. 1991 Mar;46(3):477-99.
4
3,5-Diphenyl-1H-pyrazole derivatives. VII--Esters, 2-dialkylaminoethyl ethers and N-substituted carbamates of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole with depressant and platelet antiaggregating activities.
Farmaco. 1990 May;45(5):527-43.
5
3,5-Diphenyl-1H-pyrazole derivatives. V--1-Acetyl-4-hydroxy-3,5-diphenyl-2-pyrazoline esters, 4-hydroxy-3,5-diphenyl-1H-pyrazole esters and N-substituted 4-(3-amino-2-hydroxy-1-propoxy)-1-methyl-3,5-diphenyl-1H-pyrazoles with antiarrhythmic, sedative and platelet antiaggregating activities.3,5-二苯基-1H-吡唑衍生物。V——具有抗心律失常、镇静和血小板抗聚集活性的1-乙酰基-4-羟基-3,5-二苯基-2-吡唑啉酯、4-羟基-3,5-二苯基-1H-吡唑酯以及N-取代的4-(3-氨基-2-羟基-1-丙氧基)-1-甲基-3,5-二苯基-1H-吡唑
Farmaco. 1990 Feb;45(2):147-66.
6
3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities.3,5-二苯基-1H-吡唑衍生物。XI. N-芳基-5(3)-苯基-4-(3,5-二苯基-1-吡唑基)-3(5)-吡唑胺、5-取代的4,5-二氢-3-苯基-4-(3,5-二苯基-1-吡唑基)-1H-吡唑以及具有解热、抗炎和其他活性的2,6-二取代-1,6-二氢-4-苯基-5-(3,5-二苯基-1-吡唑基)嘧啶
Farmaco. 1993 Jul;48(7):949-66.
7
3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities.3,5-二苯基-1H-吡唑衍生物。IX。具有血小板抗聚集及其他活性的2-取代-4-苯基-5-(3,5-二苯基-1H-吡唑-1-基)嘧啶
Farmaco. 1992 Feb;47(2):171-90.
8
3,5-Diphenyl-1H-pyrazole derivatives. I--Esters and N-substituted carbamates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with depressant, antiarrhythmic, analgesic and other activities.
Farmaco Sci. 1988 Sep;43(9):725-43.
9
N-arylsubstituted-1-aryl-3,4-diphenyl-5-pyrazole amines with analgesic and antiarrhythmic properties.具有镇痛和抗心律失常特性的N-芳基取代的1-芳基-3,4-二苯基-5-吡唑胺
Farmaco. 1997 Oct;52(10):615-8.
10
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities.
Farmaco. 1994 Sep;49(9):533-40.

引用本文的文献

1
Synthesis and Characterization of Pyrazole-Enriched Cationic Nanoparticles as New Promising Antibacterial Agent by Mutual Cooperation.通过相互协作合成并表征富含吡唑的阳离子纳米颗粒作为新型有前景的抗菌剂
Nanomaterials (Basel). 2022 Apr 5;12(7):1215. doi: 10.3390/nano12071215.