具有镇痛和抗心律失常特性的N-芳基取代的1-芳基-3,4-二苯基-5-吡唑胺
N-arylsubstituted-1-aryl-3,4-diphenyl-5-pyrazole amines with analgesic and antiarrhythmic properties.
作者信息
Bruno O, Schenone S, Ranise A, Bondavalli F, Falcone G, Filippelli W, Marabese I, Motula G
机构信息
Istituto di Scienze Farmaceutiche dell'Università, Genova.
出版信息
Farmaco. 1997 Oct;52(10):615-8.
PMID:9507673
Abstract
A series of N-aryl substituted-1-aryl-3,4-diphenyl-5-pyrazole amines was synthesized and evaluated for antiinflammatory, antihypertensive and platelet antiaggregating activities. Several of them were found to exhibit a significant analgesic and antiarrhythmic activity.
摘要
合成了一系列N-芳基取代的-1-芳基-3,4-二苯基-5-吡唑胺，并对其抗炎、抗高血压和血小板抗聚集活性进行了评估。发现其中几种具有显著的镇痛和抗心律失常活性。
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