Emerson C S, Vink R
Department of Chemistry and Biochemistry, James Cook University of North Queensland, Townsville, Australia.
Neuroreport. 1992 Nov;3(11):957-60. doi: 10.1097/00001756-199211000-00002.
Male and female Sprague-Dawley rat siblings (200-350 g) were monitored by phosphorus magnetic resonance spectroscopy for 4 h after moderate (2.8 atmospheres) fluid-percussion-induced traumatic brain injury. Following injury, two of nine male animals died whereas 100% of all female rats (n = 16) died (p < 0.01). Prior to injury, brain free magnesium concentration in males was 0.58 +/- 0.05 mM and in females 0.41 +/- 0.09. After injury, mean brain free magnesium concentration in males declined to 0.32 +/- 0.06 whereas mean brain free magnesium concentration in ventilated females (n = 6) after injury declined to 0.17 +/- 0.03 (p < 0.05). There were no significant differences between groups with respect to any other measured variables. We conclude that female rats are more susceptible to irreversible injury after brain trauma, and that this increased susceptibility to injury may be related to brain free magnesium levels.
对雄性和雌性Sprague-Dawley大鼠同胞（体重200 - 350克）进行中度（2.8个大气压）液压冲击诱导的创伤性脑损伤后，通过磷磁共振波谱监测4小时。受伤后，9只雄性动物中有2只死亡，而所有雌性大鼠（n = 16）全部死亡（p < 0.01）。受伤前，雄性大鼠脑游离镁浓度为0.58±0.05 mM，雌性为0.41±0.09。受伤后，雄性大鼠脑游离镁平均浓度降至0.32±0.06，而通气雌性大鼠（n = 6）受伤后脑游离镁平均浓度降至0.17±0.03（p < 0.05）。在任何其他测量变量方面，各组之间均无显著差异。我们得出结论，雌性大鼠在脑外伤后更易受到不可逆损伤，且这种对损伤易感性的增加可能与脑游离镁水平有关。
