Vink R, McIntosh T K, Demediuk P, Faden A I
Department of Neurology, University of California, San Francisco.
Biochem Biophys Res Commun. 1987 Dec 16;149(2):594-9. doi: 10.1016/0006-291x(87)90409-8.
31P magnetic resonance spectroscopy was used to determine the intracellular free Mg2+ concentration prior to and following fluid percussion induced traumatic brain injury in rats. Prior to injury, cerebral intracellular free Mg2+ concentration in the rat was 0.93 +/- 0.19 mM (mean +/- SE; n = 5). Following injury, free Mg2+ in the injured cortex declined by 70% within the first hour, and did not recover over the next 3 hours. Total Mg2+ also declined by 10% over this time period; however, there were no changes in brain Na+ or tissue water content. Because of its primary role in cellular metabolism, the early decline in tissue Mg2+ following brain trauma may be a critical factor in the development of irreversible tissue injury.
采用31P磁共振波谱法测定大鼠液压冲击诱导创伤性脑损伤前后的细胞内游离Mg2+浓度。损伤前，大鼠脑内细胞内游离Mg2+浓度为0.93±0.19 mM（平均值±标准误；n = 5）。损伤后，损伤皮质中的游离Mg2+在第一小时内下降了70%，并在接下来的3小时内未恢复。在此期间，总Mg2+也下降了10%；然而，脑内Na+或组织含水量没有变化。由于其在细胞代谢中的主要作用，脑外伤后组织Mg2+的早期下降可能是不可逆组织损伤发展的关键因素。
