Guiol C, Ledoussal C, Surgé J M
Department of Pharmacology, Bristol-Myers Squibb Pharmaceutical Research Institute, Lognes, France.
J Pharmacol Toxicol Methods. 1992 Sep;28(2):99-105. doi: 10.1016/1056-8719(92)90054-5.
Chronic measurements of systemic arterial blood pressure and heart rate via a chronically implanted telemetric transmitter in unrestrained rats, was validated in a three-phase study. In the first part, week-to-week variability of systolic, diastolic, and mean arterial pressures, and heart rate was found to be minimal over the course of nine weeks. In the second part, the reproducibility of cardiovascular response to three successive administration of sotalol, an antihypertensive agent, was studied. In the last part, cardiovascular parameters determined by telemetry were compared to those obtained by direct arterial catheterization and showed a good linear correlation between those two methods.
通过在未受约束的大鼠体内长期植入遥测发射器来对全身动脉血压和心率进行长期测量，这一方法在一项分三个阶段的研究中得到了验证。在第一部分中，发现在九周的时间里，收缩压、舒张压、平均动脉压和心率的周与周之间的变异性极小。在第二部分中，研究了抗高血压药物索他洛尔连续三次给药后心血管反应的可重复性。在最后一部分中，将通过遥测确定的心血管参数与通过直接动脉插管获得的参数进行了比较，结果表明这两种方法之间具有良好的线性相关性。
