Brockway B P, Mills P A, Azar S H
Data Sciences, Inc., St. Paul MN 55113.
Clin Exp Hypertens A. 1991;13(5):885-95. doi: 10.3109/10641969109042094.
Accurate continuous chronic measurements of blood pressure from conscious laboratory rats are critical to many experimental protocols but have been difficult or impossible to acquire. A system consisting of an implantable radio-telemetry device, receiver, and computer-based data acquisition system that allows such measurements to be easily obtained has been developed. This system is capable of monitoring and recording arterial pressure (waveform, systolic, diastolic, and mean), heart rate, and activity from rats weighing greater than 175 gm for periods in excess of 6 months. Chronic patency has been achieved through a patented design which includes an antithrombogenic film and a gel membrane located at the catheter tip. Validation of telemetered measurements via carotid catheter has demonstrated the accuracy to be better than +/- 5 mmHg in 85% (N = 20) tested at 3 weeks post implantation, 86% (N = 15) tested at 8 weeks, and 78% (N = 9) at 12 weeks. Incidence of loss of patency was 2.3% (N = 44). This system has a demonstrated ability to obtain accurate continuous chronic measurements of arterial pressure free of the stressors associated with conventional systems.
对清醒实验大鼠进行准确的慢性血压连续测量对许多实验方案至关重要，但一直难以或无法实现。现已开发出一种系统，该系统由植入式无线电遥测装置、接收器和基于计算机的数据采集系统组成，可轻松进行此类测量。该系统能够监测和记录体重超过175克的大鼠的动脉血压（波形、收缩压、舒张压和平均压）、心率和活动情况，监测时间超过6个月。通过一项专利设计实现了长期通畅，该设计包括位于导管尖端的抗血栓形成膜和凝胶膜。通过颈动脉导管对遥测测量进行验证，结果表明，在植入后3周测试的85%（N = 20）、8周测试的86%（N = 15）和12周测试的78%（N = 9）中，测量准确性优于±5 mmHg。通畅性丧失的发生率为2.3%（N = 44）。该系统已证明有能力获得准确的动脉血压慢性连续测量值，且不受传统系统相关应激因素的影响。
