静脉注射硝酸甘油与肝素之间药物相互作用的评估。
Assessment of the drug interaction between intravenous nitroglycerin and heparin.
作者信息
Gonzalez E R, Jones H D, Graham S, Elswick R K
机构信息
Department of Pharmacy and Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond.
出版信息
Ann Pharmacother. 1992 Dec;26(12):1512-4. doi: 10.1177/106002809202601203.
OBJECTIVE
To assess whether a clinically significant interaction occurs between heparin and nitroglycerin (NTG).
METHODOLOGY
Activated partial thromboplastin time (APTT) was measured in patients with unstable angina who were stabilized on intravenous NTG and heparin just prior to weaning the NTG infusion, and one and four hours after stopping the NTG.
RESULTS
In 22 heparin-treated patients (20 men, 2 women; aged 56.7 +/- 10 years; weight 79.5 +/- 15 kg), the APTT ratio was inversely related to the dose of NTG (slope = -0.003; p < 0.05). However, there were no significant differences between the APTT values measured before and after discontinuation of NTG (p = 0.8511).
CONCLUSIONS
Our study demonstrates a clinically insignificant interaction between NTG and heparin at NTG doses commonly used in patients.
目的
评估肝素与硝酸甘油（NTG）之间是否存在具有临床意义的相互作用。
方法
在不稳定型心绞痛患者中测量活化部分凝血活酶时间（APTT），这些患者在停止输注NTG之前已通过静脉输注NTG和肝素实现病情稳定，在停止NTG后1小时和4小时进行测量。
结果
在22例接受肝素治疗的患者中（20例男性，2例女性；年龄56.7±10岁；体重79.5±15千克），APTT比值与NTG剂量呈负相关（斜率=-0.003；p<0.05）。然而，停止NTG前后测量的APTT值之间无显著差异（p=0.8511）。
结论
我们的研究表明，在患者常用的NTG剂量下，NTG与肝素之间存在临床意义不显著的相互作用。
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