Bode V, Welzel D, Franz G, Polensky U
Department of Chemistry and Pharmacology, University of Regensburg, West Germany.
Arch Intern Med. 1990 Oct;150(10):2117-9.
The purpose of this randomized crossover study was to determine whether nitroglycerin interacts with heparin in terms of its anticoagulative properties as determined by activated partial thromboplastin time and thrombin time. Eight healthy adults were given either a 60-minute intravenous infusion of 5 mg of nitroglycerin or a 0.9% sodium chloride solution subsequent to the administration of an intravenous injection of 5000 U of heparin. No nitroglycerin-related drug interference with heparin was observed as measured by the activated partial thromboplastin time and the thrombin time.
这项随机交叉研究的目的是，根据活化部分凝血活酶时间和凝血酶时间所确定的抗凝特性，来判定硝酸甘油是否与肝素相互作用。在静脉注射5000 U肝素后，8名健康成年人分别接受了60分钟静脉输注5 mg硝酸甘油或0.9%氯化钠溶液。通过活化部分凝血活酶时间和凝血酶时间测定，未观察到硝酸甘油对肝素产生药物干扰。
