Coad S, Newhook R C
Bureau of Chemical Hazards, Health and Welfare Canada, Ottawa, Ontario.
J Expo Anal Environ Epidemiol. 1992 Oct-Dec;2(4):391-413.
Pentachlorophenol (PCP) is ubiquitous in the Canadian environment, as a result of the large quantities used in the wood preservation and wood protection industries. In the past decade, agricultural and wood protection applications of PCP in Canada have been sharply curtailed. A multimedia approach was used to update estimates of PCP exposure of the members of the general population in Canada, based on currently available information. A detailed review of PCP concentrations reported in air, water, foods, household dust, and soil was performed. PCP intake estimates for infants, toddlers, school-age children, and adults in Canada were calculated. Estimates were made for people with average intakes of air, water, foods, household dust, and soil, as well as for recreational anglers and aboriginal subsistence fishermen, who were expected to have higher intakes. The current estimated intake by all of these populations is well below the Acceptable Daily Intake (ADI) of 6 micrograms/kg bw/day. The average members of the general population have an estimated intake via all routes of 0.05 micrograms/kg bw/day; most exposure is calculated to occur via food (dairy products, grains and cereals and meats) and indoor air. Recreational anglers are estimated to be exposed to only marginally more PCP per day (roughly 2%) than the general population. In contrast, aboriginal subsistence fisherman, because of their very high consumption of fish and fish products, experience the highest exposure to PCP through food; their estimated intake of PCP is almost twice that of the general population.
由于木材防腐和木材保护行业大量使用五氯苯酚(PCP),它在加拿大环境中广泛存在。在过去十年中,加拿大农业和木材保护领域对PCP的使用已大幅减少。基于现有信息,采用多媒体方法更新了加拿大普通人群PCP暴露量的估计值。对空气、水、食品、家庭灰尘和土壤中报告的PCP浓度进行了详细审查。计算了加拿大婴儿、幼儿、学龄儿童和成年人的PCP摄入量估计值。对空气、水、食品、家庭灰尘和土壤平均摄入量人群,以及预计摄入量较高的休闲垂钓者和原住民自给渔民进行了估计。目前所有这些人群的估计摄入量远低于每日可接受摄入量(ADI)6微克/千克体重/天。普通人群的平均摄入量估计通过所有途径为0.05微克/千克体重/天;大部分暴露量经计算是通过食物(乳制品、谷物和肉类)和室内空气发生的。估计休闲垂钓者每天接触的PCP仅比普通人群略多(约2%)。相比之下,原住民自给渔民由于鱼类和鱼类产品消费量极高,通过食物接触PCP的量最大;他们的PCP估计摄入量几乎是普通人群的两倍。