Harvey J N, Gray C, Belchetz P E
Department of Endocrinology, General Infirmary at Leeds, UK.
Clin Endocrinol (Oxf). 1992 Oct;37(4):379-82. doi: 10.1111/j.1365-2265.1992.tb02342.x.
An example of oncogenous osteomalacia is described in association with the rate mesenchymal chondroblastoma. The tumour was characterized with a variety of immunohistochemical antibodies which confirmed its mesenchymal origin. Despite several surgical excisions of local recurrence, plasma 1,25-dihydroxyvitamin D3 concentrations (off treatment) indicate continued tumour activity and the continuing need for vitamin D therapy. This case and two others briefly discussed illustrate some of the difficulties in diagnosis and in achieving a cure in cases of oncogenous osteomalacia. Oncogenous osteomalacia in association with any malignant tumour is rare, there being eight previously recorded cases. Details of these cases are briefly reviewed for comparison. Despite undoubted malignancy our patient has survived 30 years from presentation indicating the benefits of aggressive surgical management.
本文描述了一例与低级别间叶性软骨肉瘤相关的致癌性骨软化症病例。该肿瘤通过多种免疫组化抗体进行特征性分析，证实了其间叶起源。尽管对局部复发进行了多次手术切除，但血浆1,25 - 二羟维生素D3浓度（未接受治疗时）表明肿瘤仍在持续活动，且持续需要维生素D治疗。该病例以及另外两个简要讨论的病例说明了致癌性骨软化症病例在诊断和实现治愈方面存在的一些困难。与任何恶性肿瘤相关的致癌性骨软化症都很罕见，此前有8例记录在案。简要回顾了这些病例的详细信息以供比较。尽管患者无疑患有恶性肿瘤，但自确诊以来已存活30年，这表明积极的手术治疗有益。
