Janin A, Morel P, Quiquandon I, Farre I, Hatron P Y, Bauters F, Gosselin B
Department of Pathology C, Hôpital Calmette, Lille, France.
Clin Exp Rheumatol. 1992 Nov-Dec;10(6):565-70.
One hundred and thirteen patients with untreated non-Hodgkin's lymphoma were evaluated for Sjögren's syndrome (SS) using clinical and biological parameters, and a minor salivary gland biopsy. Concomitant immunophenotyping for T and B cells, and kappa and lambda chains was performed on both minor salivary gland and lymphomatous tissues. Patients with a positive focus score on examination of their minor salivary gland biopsy had a second biopsy, when possible, at the end of induction therapy. Fourteen of the 113 patients had SS according to the Greek criteria, and 4 of these 14 patients had an identical monotypic infiltrate in both their minor salivary gland and lymphomatous tissues. In all four cases this infiltrate disappeared from both locations when the lymphoma was in complete remission (CR). The 10 other patients with criteria for SS had a mixed infiltrate which persisted unchanged when the lymphoma was in CR. Among the 99 patients without SS, 12 had a positive focus score and an identical monotypic infiltrate in both their minor salivary gland and lymphomatous tissue. This infiltrate disappeared from both locations when the lymphoma was in CR. Among the remaining 87 patients, 82 had no minor salivary gland infiltrate, and 5 had a positive focus score with mixed lymphocytic infiltrate. Long term follow up and a large cooperative study are needed to better understand the immunopathologic lesions of patients of this latter type.
对113例未经治疗的非霍奇金淋巴瘤患者，采用临床和生物学参数以及小唾液腺活检对干燥综合征（SS）进行评估。对小唾液腺和淋巴瘤组织均进行T细胞、B细胞以及κ链和λ链的伴随免疫表型分析。小唾液腺活检检查时聚焦评分阳性的患者，在诱导治疗结束时尽可能进行第二次活检。根据希腊标准，113例患者中有14例患有SS，这14例患者中有4例在小唾液腺和淋巴瘤组织中均有相同的单型浸润。在所有4例病例中，当淋巴瘤完全缓解（CR）时，两个部位的浸润均消失。其他10例符合SS标准的患者有混合浸润，当淋巴瘤处于CR时，浸润持续不变。在99例无SS的患者中，12例在小唾液腺和淋巴瘤组织中聚焦评分阳性且有相同的单型浸润。当淋巴瘤处于CR时，该浸润在两个部位均消失。在其余87例患者中，82例无小唾液腺浸润，5例聚焦评分阳性且有混合淋巴细胞浸润。需要长期随访和大型合作研究以更好地了解后一种类型患者的免疫病理损伤。
