Easley C S, Wartman F S, Kopelman A E, Louis T M
Department of Pediatrics, East Carolina University School of Medicine, Greenville, N.C. 27858-4353.
Dev Pharmacol Ther. 1992;18(1-2):65-70.
We examined the effect of the calcium channel blocker nimodipine on postischemic hypoperfusion in the newborn piglet brain. A severe pneumothorax (SP) was induced by injecting air into the right thorax until the mean arterial blood pressure fell to 25% of baseline and was maintained for 4 min. Blood flow was immediately reduced 70-90% from baseline in each brain region during SP. In untreated animals postischemic hypoperfusion existed at 60 min, following recovery from SP with regional brain blood flow reduced 20-30% from baseline. Nimodipine infusion after SP prevented postischemic hypoperfusion in all brain regions and increased blood flows by as much as 40% above baseline in midbrain and brainstem structures. Nimodipine infusion began after severe brain ischemia prevented postischemic hypoperfusion and enhanced brain blood flow in this model.
我们研究了钙通道阻滞剂尼莫地平对新生仔猪脑缺血后低灌注的影响。通过向右侧胸腔注入空气诱导严重气胸（SP），直至平均动脉血压降至基线的25%并维持4分钟。在SP期间，每个脑区的血流立即从基线减少70 - 90%。在未经治疗的动物中，从SP恢复后60分钟存在缺血后低灌注，局部脑血流比基线减少20 - 30%。SP后输注尼莫地平可防止所有脑区出现缺血后低灌注，并使中脑和脑干结构的血流比基线增加多达40%。在严重脑缺血后开始输注尼莫地平可防止缺血后低灌注并增加该模型中的脑血流量。
