Carmody J, Lilly J K
West Virginia School of Medicine, Charleston Division.
W V Med J. 1990 Feb;86(2):49-51.
Nimodipine is a 1,4 dihydropyridine with Ca++ channel blocking properties. It is more lipophilic than most calcium channel blockers, and thus has a greater volume of distribution within the brain. Many actions of nimodipine have been proposed from work done in animal models following induction of complete or partial cerebral ischemia for varying lengths of time. However, these experimental results have not been sufficiently documented in patient populations, and there exists conflicting data as to nimodipine's mechanism of action in the cerebral ischemic patient. Regardless of the exact mechanisms of action, studies suggest that nimodipine may significantly reduce morbidity and mortality in patients following disruption of cerebral blood flow.
尼莫地平是一种具有钙离子通道阻滞特性的1,4 - 二氢吡啶。它比大多数钙通道阻滞剂更具亲脂性，因此在脑内的分布容积更大。在动物模型中，对不同时长的完全或部分脑缺血进行诱导后开展的研究提出了尼莫地平的多种作用。然而，这些实验结果在患者群体中尚未得到充分证实，关于尼莫地平在脑缺血患者中的作用机制也存在相互矛盾的数据。无论确切的作用机制如何，研究表明尼莫地平可能会显著降低脑血流中断患者的发病率和死亡率。
