Pinotti G, Novario R, Berrino F, Bianchi P, Comi M A, Gamba M C, Venco A
Clinica Medica, Università di Pavia, Sede di Varese, Italy.
Haematologica. 1992 Sep-Oct;77(5):405-12.
The incidence of primary gastric non-Hodgkin's lymphoma (NHL) appears to have increased worldwide in recent years, and this seems to be confirmed by large-sample population studies.
We derived our data from the Lombardy Cancer Registry, which provides the incidence of cancer in the province of Varese, Northern Italy. From 1978 to 1987 we identified 3261 cases of gastric neoplasms, 119 of which were gastric NHL: 32 (1.87%) from 1978 to 1982, and 87 (5.32%) from 1983 to 1987. The difference in the age and sex standardized incidence trend between these two time periods was statistically significant (p < 0.001). The overall survival rate of the 112 evaluable patients was 54% at 5 years and 45% at 10 years. A multivariate analysis was performed. Age (p < 0.0005), clinical stage (p < 0.04) and therapy (p < 0.0005) were found to be significant prognostic factors for survival.
This study stresses the utility of prospective randomized clinical trials that could indicate the optimal management of patients with primary gastric lymphoma.
近年来，原发性胃非霍奇金淋巴瘤（NHL）的发病率在全球范围内似乎有所上升，这似乎已得到大样本群体研究的证实。
我们的数据来源于伦巴第癌症登记处，该登记处提供了意大利北部瓦雷泽省的癌症发病率。1978年至1987年期间，我们共识别出3261例胃肿瘤病例，其中119例为胃NHL：1978年至1982年有32例（1.87%），1983年至1987年有87例（5.32%）。这两个时间段之间年龄和性别标准化发病率趋势的差异具有统计学意义（p < 0.001）。112例可评估患者的5年总生存率为54%，10年总生存率为45%。进行了多因素分析。发现年龄（p < 0.0005）、临床分期（p < 0.04）和治疗方式（p < 0.0005）是生存的重要预后因素。
本研究强调了前瞻性随机临床试验的实用性，这类试验可以为原发性胃淋巴瘤患者指明最佳治疗方案。
