Pozzato G, Franzin F, Moretti M, Tulissi P, Pecorari P, Melato M, Zacchi T, Evangelisti P, Campanacci L
Istituto di Patologia Medica, Facoltà di Medicina, Università di Trieste, Italy.
Haematologica. 1992 Sep-Oct;77(5):413-7.
Alpha-interferon (alpha-IFN) was found to have a good antiproliferative effect in early stage chronic lymphocytic leukemia (CLL), but recombinant alpha-IFN administration may induce serious side effects. Therefore low-dose "natural" IFN was evaluated in terms of efficacy and safety.
Fifteen patients affected by stage A (according to Binet) B-CLL underwent the treatment: natural IFN 1 MU three times a week for 6 months.
Overall lymphocyte count decreased from 13,050 +/- 3,200 to 7,500 +/- 2,940 within 6 months. One patient did not respond to IFN therapy. No one complained of side effects.
Low dose "natural" alpha-IFN seems useful and well tolerated in CLL, but the potential curative role of IFN in CLL remains to be established.
α-干扰素（α-IFN）在早期慢性淋巴细胞白血病（CLL）中具有良好的抗增殖作用，但重组α-IFN给药可能会引起严重的副作用。因此，对低剂量“天然”干扰素的疗效和安全性进行了评估。
15例A期（根据比内分期）B-CLL患者接受了治疗：天然干扰素1MU，每周3次，共6个月。
6个月内，总淋巴细胞计数从13,050±3,200降至7,500±2,940。1例患者对干扰素治疗无反应。无人抱怨有副作用。
低剂量“天然”α-干扰素在CLL中似乎有用且耐受性良好，但干扰素在CLL中的潜在治愈作用仍有待确定。
