Häring H U
III. Medizinische Abteilung, Städtisches Krankenhaus München-Schwabing.
Fortschr Med. 1992 Dec 10;110(34):633-6.
The metabolic syndrome (syndrome X) is characterised by an association of elevated insulin levels, a tendency to obesity of the android type, a disturbance of lipid metabolism with elevated triglyceride levels and commonly associated hypertension. The underlying common cause of this syndrome appears to be insulin resistance of the skeletal muscles, which is related in particular to the non-oxidative glucose utilization on the part of the muscle. The molecular cause of this syndrome has not been clarified, but a defect in the signal transduction chain between the insulin receptor and glycogen synthase is suspected. Epidemiological studies have shown that the metabolic syndrome may be considered a preliminary stage of manifest type II diabetes. In addition, it appears to play a major role in the development of cardiovascular complications in certain high-risk groups.
代谢综合征（X综合征）的特征是胰岛素水平升高、向心性肥胖倾向、脂质代谢紊乱伴甘油三酯水平升高以及常伴有高血压。该综合征潜在的共同病因似乎是骨骼肌的胰岛素抵抗，这尤其与肌肉的非氧化葡萄糖利用有关。此综合征的分子病因尚未阐明，但怀疑在胰岛素受体和糖原合酶之间的信号转导链存在缺陷。流行病学研究表明，代谢综合征可被视为显性II型糖尿病的前期阶段。此外，它似乎在某些高危人群心血管并发症的发生中起主要作用。
