Häring H U
Institut für Diabetes-Forschung, München.
Z Gesamte Inn Med. 1993 Mar;48(3):108-11.
The metabolic syndrome (syndrome X) is characterized by elevated insulin levels, obesity of the android type, disturbed lipid metabolism with increased triglycerides (VLDL elevated, HDL decreased) and an association with hypertension. The cause of this syndrome appears to be an insulin resistance of the skeletal muscle. The molecular mechanism leading to skeletal muscle insulin resistance is not understood, however an abnormality of signal transduction from the insulin receptor to glycogen synthase is suggested. It is believed that this syndrome represents a potentially prediabetic situation. Furthermore it is believed that this syndrome gives rise to cardiovascular complications in certain predisposed populations.
代谢综合征（X综合征）的特征为胰岛素水平升高、腹型肥胖、脂质代谢紊乱（甘油三酯升高，极低密度脂蛋白升高，高密度脂蛋白降低）以及与高血压相关。该综合征的病因似乎是骨骼肌的胰岛素抵抗。然而，导致骨骼肌胰岛素抵抗的分子机制尚不清楚，不过有研究提示胰岛素受体至糖原合酶的信号转导存在异常。据信，该综合征代表一种潜在的糖尿病前期状态。此外，据信该综合征会在某些易感人群中引发心血管并发症。
