Yassin N, Büchler M, Uhl W, Scherbaum W A
Department of Internal Medicine, University of Ulm, Germany.
Hepatogastroenterology. 1992 Dec;39(6):533-5.
Antineutrophil cytoplasmic autoantibodies, which are now considered reliable serological markers of acute necrotizing vasculitic diseases, were measured in 11 patients with acute necrotizing pancreatitis and 12 patients with acute interstitial pancreatitis. When tested by indirect immunofluorescence, none of the sera was positive for diffuse cytoplasmic staining, and none was positive for perinuclear staining of antineutrophil cytoplasmic antibodies. Also by the sensitive enzyme-linked immunosorbent assay, none of the sera was positive when purified alpha-granule fraction of granulocytes was used as an antigen. We can therefore conclude that neither the diffuse cytoplasm-reacting, nor the perinuclear form of antineutrophil cytoplasmic antibodies, is involved in cases of acute pancreatitis.
在11例急性坏死性胰腺炎患者和12例急性间质性胰腺炎患者中检测了抗中性粒细胞胞浆自身抗体，该抗体目前被认为是急性坏死性血管炎疾病可靠的血清学标志物。通过间接免疫荧光检测时，所有血清的弥漫性胞浆染色均为阴性，抗中性粒细胞胞浆抗体的核周染色也均为阴性。同样通过灵敏的酶联免疫吸附测定法，当使用纯化的粒细胞α颗粒部分作为抗原时，所有血清均为阴性。因此我们可以得出结论，无论是弥漫性胞浆反应性抗中性粒细胞胞浆抗体，还是核周形式的抗中性粒细胞胞浆抗体，均不参与急性胰腺炎病例。
