Le Roux G, Larmignat P, Marchal M, Richalet J P
ARPE, UFR Médecine, Bobigny, France.
Int J Sports Med. 1992 Oct;13 Suppl 1:S49-51. doi: 10.1055/s-2007-1024592.
Haemostasis has been studied by several authors during exposure to altitude hypoxia. On acute induction to hypoxia, platelet count, platelet aggregability and bleeding time are normal; an increase of thromboxane released from platelets and of prostacyclin, released from endothelial cells is observed; coagulation factors are unchanged except of F. VIII which is increased; modified antithrombin III (ATm) are normal; fibrinopeptide A is increased in subjects with pulmonary edema and fibrinolytic activity after venous occlusion is normal. In chronic hypoxia, during a stay at 6542 m (Mt. Sajama), we found in 7 subjects an important increase in D. Dimer (p < 0.001) that seems to correspond to an activation of coagulation and a decrease of F. VIII R. Cof/F. VIII R. Ag ratio which suggests an endothelial cell damage.
几位作者对暴露于高原低氧环境下的止血情况进行了研究。在急性低氧诱导时，血小板计数、血小板聚集性和出血时间均正常；观察到血小板释放的血栓素和内皮细胞释放的前列环素增加；除因子VIII增加外，凝血因子无变化；改良抗凝血酶III（ATm）正常；肺水肿患者的纤维蛋白肽A增加，静脉阻塞后的纤溶活性正常。在慢性低氧环境下，在海拔6542米（萨哈马火山）停留期间，我们发现7名受试者的D - 二聚体显著增加（p < 0.001），这似乎与凝血激活有关，同时因子VIII R：Cof/因子VIII R：Ag比值降低，提示存在内皮细胞损伤。
