环孢菌素A在极性溶剂中的构象。

Conformation of cyclosporin A in polar solvents.

作者信息

Ko S Y, Dalvit C

机构信息

Preclinical Research, Sandoz Pharma AG, Basel, Switzerland.

出版信息

Int J Pept Protein Res. 1992 Nov;40(5):380-2. doi: 10.1111/j.1399-3011.1992.tb00314.x.

DOI:10.1111/j.1399-3011.1992.tb00314.x

PMID:1483832

Abstract

A major conformation of cyclosporin A in methanol and in aqueous methanol was revealed by some simple NMR experiments. Thus, a stepwise transition of cyclosporin A conformation from 100% CDCl3 to 100% CD3OD was followed by 1H NMR, which showed that the chloroform conformation of cyclosporin A was still the major one in methanol. Employing the same technique, it was also shown that the chloroform conformation of cyclosporin A was one of the major conformations in 50% aqueous methanol. This may be the first experimental determination of a major conformation of cyclosporin A in polar solvents.

摘要

通过一些简单的核磁共振实验揭示了环孢菌素A在甲醇和甲醇水溶液中的主要构象。因此，用1H核磁共振跟踪环孢菌素A构象从100% CDCl3到100% CD3OD的逐步转变，结果表明环孢菌素A的氯仿构象在甲醇中仍是主要构象。采用相同技术还表明，环孢菌素A的氯仿构象是50%甲醇水溶液中的主要构象之一。这可能是首次对环孢菌素A在极性溶剂中的主要构象进行实验测定。