Rhyan J C, Sartin E A, Powers R D, Wolfe D F, Dowling P M, Spano J S
Pathobiology Laboratory, USDA, Ames, IA 50010.
J Am Vet Med Assoc. 1992 Dec 15;201(12):1907-10.
Severe renal oxalosis was diagnosed in 4 male and 1 female purebred Beefmaster calves from herds in southeastern and northwestern United States. Clinical signs included weakness, anorexia, lethargy, alopecia, dehydration, and diarrhea. Results of serum biochemical analysis for 2 calves were consistent with end-stage renal disease. Calves died 2 days to 6 weeks after birth. At necropsy, renal calyces were dilated and contained pale yellow granular calculi. Histologically, there was renal interstitial fibrosis, and cortical and medullary tubules were distended with calcium oxalate crystals. Oxalate crystals were also in the tracheal glands of 1 calf. Severe renal oxalosis in young purebred calves, on widely varied diets, with no known exposure to exogenous oxalates is suggestive of an inherited metabolic defect resulting in primary hyperoxaluria.
在美国东南部和西北部牛群中，4头雄性和1头雌性纯种肉牛犊被诊断出患有严重肾草酸沉着症。临床症状包括虚弱、厌食、嗜睡、脱毛、脱水和腹泻。2头犊牛的血清生化分析结果与终末期肾病一致。犊牛在出生后2天至6周内死亡。尸检时，肾盏扩张，含有淡黄色颗粒状结石。组织学检查显示，存在肾间质纤维化，皮质和髓质小管内充满草酸钙晶体。1头犊牛的气管腺中也有草酸钙晶体。饮食差异很大且无已知外源性草酸盐接触史的年轻纯种犊牛出现严重肾草酸沉着症，提示存在导致原发性高草酸尿症的遗传性代谢缺陷。
