Kobayashi H, Ikada Y, Moritera T, Ogura Y, Honda Y
Research Center for Biomedical Engineering, Kyoto University, Japan.
J Biomed Mater Res. 1992 Dec;26(12):1583-98. doi: 10.1002/jbm.820261205.
The purpose of this study was to compare the tissue reactions induced by modified poly(vinyl alcohol) (PVA) hydrogels with other materials implanted in the rabbit cornea. PVA hydrogels with and without covalently bonded collagen were compared to ethylene-vinyl alcohol copolymer, and polysulfone discs. These materials were implanted in the rabbit corneal stroma. The resultant tissue reactions were histologically and clinically studied. The PVA hydrogels had high flux rates of glucose and L-lactic acid in vitro. Covalent immobilization of collagen onto their surface was found to render them more biocompatible. However, excessive ulceration and vascularization of the cornea still occurred in vivo, possibly because of extremely little blinking of the rabbits, which might cause desiccation of the cornea.
本研究的目的是比较改性聚乙烯醇（PVA）水凝胶与植入兔角膜的其他材料所引发的组织反应。将共价结合胶原蛋白和未共价结合胶原蛋白的PVA水凝胶与乙烯-乙烯醇共聚物及聚砜圆盘进行比较。这些材料被植入兔角膜基质中。对由此产生的组织反应进行了组织学和临床研究。PVA水凝胶在体外具有较高的葡萄糖和L-乳酸通量率。发现胶原蛋白共价固定在其表面可使其生物相容性更高。然而，在体内角膜仍出现过度溃疡和血管化现象，这可能是因为兔子眨眼极少，可能导致角膜干燥。
