Blin J, Vidailhet M J, Pillon B, Dubois B, Feve J R, Agid Y
Service de Neurologie et Neuropsychologie, Hôpital de la Salpêtrière, Paris, France.
Mov Disord. 1992 Oct;7(4):348-54. doi: 10.1002/mds.870070409.
Cerebral energy metabolism was studied by positron emission tomography and [18F]fluorodeoxyglucose in five patients with clinical diagnoses of probable corticobasal degeneration. A reduction in glucose consumption was observed in most cortical and subcortical structures compared to age-matched controls. The reduction was greatest on the side of the brain contralateral to the most affected limbs, as shown by the significantly lower ratios of contralateral to homolateral metabolic rates, in the temporal and sensorimotor cortex of patients compared to controls. A distinct asymmetry between the two hemispheres could be observed in a patient who was examined twice in the course of his illness. Detection of this asymmetrical decrease in brain cortical and subcortical glucose metabolism may prove useful as additional evidence supporting clinical diagnoses of the disease.
采用正电子发射断层扫描术和[18F]氟脱氧葡萄糖对5例临床诊断为可能的皮质基底节变性患者的脑能量代谢进行了研究。与年龄匹配的对照组相比，大多数皮质和皮质下结构的葡萄糖消耗均减少。与对照组相比，患者颞叶和感觉运动皮层中对侧与同侧代谢率之比显著降低，表明在受影响最严重肢体对侧的大脑中，葡萄糖消耗减少最为明显。在病程中接受两次检查的一名患者中，可观察到两个半球之间存在明显不对称。检测到脑皮质和皮质下葡萄糖代谢的这种不对称性降低，可能作为支持该疾病临床诊断的额外证据而被证明是有用的。
