Kowal P
Katedry i Kliniki Neurologii, Poznaniu.
Neurol Neurochir Pol. 1992 Jul-Aug;26(4):538-44.
The HELP system is a new method of selective plasmapheresis, which decreases LDL concentration in plasma with the additional effect of lowering Lp (a) and fibrinogen, while HDL are increased during long-term treatment. The HELP system also significantly improves plasma viscosity, erythrocyte aggregation and red cells deformability. In patients with severe hypercholesterolaemia a good clinical effect of this therapy has been established. Preliminary results of the HELP system application in cerebrovascular disease indicated a clinical improvement in patients treated in this way in relation to the basic values as well as to the control group. No serious haemorrhagic or thrombotic effects have been observed during therapy, but in view of interference in coagulation and fibrinolysis this possibility should be considered.
HELP系统是一种选择性血浆置换的新方法，它可降低血浆中低密度脂蛋白（LDL）的浓度，同时还具有降低脂蛋白（a）[Lp（a）]和纤维蛋白原的附加作用，而高密度脂蛋白（HDL）在长期治疗过程中会增加。HELP系统还能显著改善血浆黏度、红细胞聚集性和红细胞变形性。在重度高胆固醇血症患者中，已证实该疗法具有良好的临床效果。HELP系统应用于脑血管疾病的初步结果表明，采用这种方法治疗的患者相对于基础值以及对照组而言，临床症状有所改善。治疗期间未观察到严重的出血或血栓形成效应，但鉴于其对凝血和纤溶的干扰作用，应考虑到这种可能性。
