Sutoo D, Akiyama K, Takita H
Department of Pediatrics, University of Tsukuba, Japan.
Physiol Behav. 1992 Nov;52(5):865-72. doi: 10.1016/0031-9384(92)90363-7.
Abnormal behavior in epileptic mice (El mice) may be rectified after convulsive seizures. This mechanism was investigated behaviorally through measurements of ethanol-induced sleeping time and locomotor activity, as well as immunohistochemically using a microphotometry system. Decreased ethanol-induced sleeping time and increased ethanol-dependent locomotor activity in El mice as compared to ddY mice (the mother strain of El mice) were rectified by convulsions as well as the intraventricular (IVT) administration of CaCl2, dopamine, or serotonin. Also, the lower dopamine levels in the neostriatum and nucleus accumbens septi in El mice as compared to ddY mice were improved by convulsions as well as the IVT administration of CaCl2. We have previously observed that a lower level of serum calcium in El mice causes a decrease in central biogenic amine synthesis through a calmodulin-dependent system. This may increase the susceptibility to epileptic convulsions and induce abnormal behavior. Combining the present results with our previous observations, we suggest that the convulsions in El mice will be induced when the balance of physiological functions is lost, as may be seen when the biogenic amine syntheses are decreased. The serum calcium level in El mice is increased by convulsions, and an elevated serum calcium level enhances brain biogenic amine synthesis through a calmodulin-dependent system. Subsequently, biogenic amines rectify physiological disorders in El mice.
癫痫小鼠（El小鼠）的异常行为在惊厥发作后可能会得到纠正。通过测量乙醇诱导的睡眠时间和运动活动，以及使用显微光度计系统进行免疫组织化学研究了这一机制。与ddY小鼠（El小鼠的母系品系）相比，El小鼠中乙醇诱导的睡眠时间减少和乙醇依赖性运动活动增加，通过惊厥以及脑室内（IVT）注射氯化钙、多巴胺或5-羟色胺得到了纠正。此外，与ddY小鼠相比，El小鼠新纹状体和伏隔核中较低的多巴胺水平通过惊厥以及IVT注射氯化钙得到了改善。我们之前观察到，El小鼠血清钙水平较低会通过钙调蛋白依赖性系统导致中枢生物胺合成减少。这可能会增加对癫痫惊厥的易感性并诱发异常行为。将目前的结果与我们之前的观察结果相结合，我们认为当生理功能平衡丧失时，如生物胺合成减少时，El小鼠会诱发惊厥。惊厥会使El小鼠的血清钙水平升高，而升高的血清钙水平会通过钙调蛋白依赖性系统增强脑生物胺合成。随后，生物胺纠正了El小鼠的生理紊乱。
