Sutoo D, Akiyama K, Takita H
Department of Pediatrics, University of Tsukuba, Japan.
Eur J Pharmacol. 1995 May 4;278(1):33-7. doi: 10.1016/0014-2999(95)00098-6.
The possible complication of hypertension and epilepsy was investigated through the response in epileptic El mice. The systolic blood pressure in El mice (male, 8 weeks of age) and that in normal ddY mice (the parent strain of El mice) were compared by a tail-cuff method, using a programmed sphygmomanometer. The systolic blood pressure in El mice (120.5 +/- 5.6 mm Hg) was 28% (P < 0.01) higher than that in ddY mice (93.9 +/- 5.3 mm Hg). The higher systolic blood pressure in El mice was lowered by the acute intracerebroventricular administration of CaCl2 (10 mumol/kg, 30 min before measurement) or dopamine (30 nmol/mouse, 15 min before measurement), and was also improved by the chronic oral supplementation with 1.2% calcium (Ca2+) solution. Combining these results with those in our previous reports, where it is stated that lowering of Ca(2+)-calmodulin-dependent catecholamine synthesis increases the susceptibility to epileptic convulsions, we suggest that the increase in susceptibility to epileptic convulsion and occurrence of hypertension in El mice may be linked and that the two diseases may be associated.
通过癫痫性El小鼠的反应，研究了高血压和癫痫可能的并发症。采用程控血压计，通过尾套法比较了El小鼠（雄性，8周龄）和正常ddY小鼠（El小鼠的亲本品系）的收缩压。El小鼠的收缩压（120.5±5.6mmHg）比ddY小鼠（93.9±5.3mmHg）高28%（P<0.01）。急性脑室内注射氯化钙（10μmol/kg，测量前30分钟）或多巴胺（30nmol/小鼠，测量前15分钟）可降低El小鼠较高的收缩压，长期口服1.2%钙（Ca2+）溶液也可改善其收缩压。将这些结果与我们之前报告中的结果相结合，之前的报告指出降低Ca（2+）-钙调蛋白依赖性儿茶酚胺合成会增加癫痫惊厥的易感性，我们认为El小鼠癫痫惊厥易感性增加和高血压的发生可能有关联，且这两种疾病可能存在关联。
