Kobashi M, Adachi A
Department of Physiology, Okayama University Dental School, Japan.
Physiol Behav. 1992 Nov;52(5):885-8. doi: 10.1016/0031-9384(92)90366-a.
To determine whether or not hepatoportal osmoreceptive (or sodium-receptive) signals participate in the control of drinking, we examined the effects of portal infusion of water, 0.9% saline, and 1.8% saline on water intake by water-deprived rats. Infusion was started 0.5 h prior to the end of the water deprivation period for 3.5 h at a rate of 52 microliters/min through either a portal or a jugular catheter. After 24-h water deprivation, water intake was measured successively for 24 h without food. As a result of the water infusion tests, water intake of the portal infusion group was significantly less than that of the jugular infusion group during and after the infusion. Portal infusion of neither 0.9% nor 1.8% saline affected the water intake compared to similar infusion into the jugular vein. It is concluded that hypotonic stimulation of the hepatoportal osmoreceptor suppresses water intake in water-deprived rats. On the contrary, isotonic or hypertonic stimulation does not produce any change of water intake.
为了确定肝门静脉渗透压感受器（或钠感受器）信号是否参与饮水控制，我们研究了通过门静脉或颈静脉导管，向缺水大鼠门静脉输注水、0.9%盐水和1.8%盐水对其饮水量的影响。在缺水期结束前0.5小时开始输注，持续3.5小时，速率为52微升/分钟。经过24小时缺水后，在不给食物的情况下连续24小时测量饮水量。水输注试验结果显示，在输注期间及输注后，门静脉输注组的饮水量显著低于颈静脉输注组。与颈静脉输注类似溶液相比，门静脉输注0.9%或1.8%盐水均不影响饮水量。得出的结论是，肝门静脉渗透压感受器的低渗刺激会抑制缺水大鼠的饮水量。相反，等渗或高渗刺激不会引起饮水量的任何变化。
