Kobashi M, Mizutani M, Adachi A
Department of Oral Physiology, Okayama University Dental School, Japan.
J Auton Nerv Syst. 1998 Nov 10;73(2-3):156-62. doi: 10.1016/s0165-1838(98)00138-6.
The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research.
研究了门静脉输注高渗和低渗溶液对大鼠胃动力的影响。向门静脉输注高渗盐水（门静脉输注）可显著增强胃收缩活动。向门静脉输注水也会产生这种增强作用。然而，向门静脉输注等渗盐水未显示出显著增强；向颈静脉输注水和高渗盐水也未显示出显著增强。切断迷走神经肝支（肝迷走神经）消除了胃动力的增强反应。因此得出结论，肝门静脉渗透压感受传入信号通过肝迷走神经影响胃动力。这些对渗透压的影响表明，低渗刺激比高渗刺激对增强动力更有效。切断包括胃背侧支和腹腔支在内的膈下迷走神经背支并未消除这些反应。相比之下，切断胃腹侧迷走神经确实消除了这些反应。这些结果表明，迷走神经左背运动核中的迷走神经节前神经元在本研究中观察到的胃动力增强中发挥作用。
