Carpinelli A R, Curi R, Malaisse W J
Department of Physiology and Biophysics, University of Sao Paulo, Brazil.
Physiol Behav. 1992 Dec;52(6):1193-6. doi: 10.1016/0031-9384(92)90481-g.
The immediate metabolic, cationic, and secretory response of the insulin-producing B-cell to D-glucose is regulated, in a delayed or long-term manner, by nutritional factors such as food availability, feeding schedule, or diet composition. The B-cell keeps the memory of these nutritional manipulations so that the corresponding changes in its responsiveness to D-glucose can be documented in vitro in isolated pancreatic islets. The results of experiments conducted in starved rats, in animals exposed to an altered feeding schedule, and in rats given free access to a high-carbohydrate, high-protein, or high-lipid, as distinct from balanced, diet all suggest that a sufficient prandial hyperglycemia is essential for maintenance of an optimal metabolic and secretory behavior of the islet B-cell in response to a rise in D-glucose concentration.
胰岛素分泌B细胞对D-葡萄糖的即时代谢、阳离子和分泌反应，会受到食物可获得性、进食时间表或饮食组成等营养因素的延迟或长期调节。B细胞会记住这些营养调控情况，以便在体外分离的胰岛中记录其对D-葡萄糖反应性的相应变化。在饥饿大鼠、进食时间表改变的动物以及自由摄取高碳水化合物、高蛋白或高脂肪（与均衡饮食不同）饮食的大鼠身上进行的实验结果均表明，充足的餐后高血糖对于维持胰岛B细胞在D-葡萄糖浓度升高时的最佳代谢和分泌行为至关重要。
