Targum S D
Department of Psychiatry, Crozier-Chester Medical Center, Upland, Pennsylvania 19013-3995.
Psychoneuroendocrinology. 1992 Oct;17(5):453-8. doi: 10.1016/0306-4530(92)90003-p.
The present study assessed the relation of cortisol response to anxiogenic reactivity during intravenous lactate infusion and oral fenfluramine in 12 panic disorder (PD) patients who responded positively to both challenges and in eight non-reactive control subjects. There was no significant cortisol response difference between the PD patients and the controls during lactate infusion, but there was s significant difference at 120 min during the fenfluramine challenge. These findings are consistent with the possibility that these challenges stimulate different neurobiologic mechanisms and that fenfluramine-precipitated anxiety is more akin to anticipatory or generalized anxiety than to true panic anxiety.
本研究评估了12名对两种激发试验均反应阳性的惊恐障碍（PD）患者和8名无反应的对照受试者在静脉输注乳酸盐和口服芬氟拉明期间皮质醇反应与致焦虑反应性之间的关系。在输注乳酸盐期间，PD患者和对照组之间的皮质醇反应无显著差异，但在芬氟拉明激发试验期间120分钟时存在显著差异。这些发现与以下可能性一致：这些激发试验刺激了不同的神经生物学机制，且芬氟拉明诱发的焦虑更类似于预期性焦虑或广泛性焦虑，而非真正的惊恐焦虑。
