慢性心力衰竭与慢性肾性贫血患者运动时的通气成本比较
The ventilatory cost of exercise compared in chronic heart failure and chronic renal anaemia.
作者信息
Lewis N P, Macdougall I C, Willis N, Henderson A H
机构信息
Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
出版信息
Q J Med. 1992 Jul;83(303):523-31.
The cardiorespiratory responses to maximal treadmill exercise were compared in matched groups of patients with chronic renal anaemia or treated chronic heart failure, and in normal controls. Exercise capacity was similarly reduced in both patient groups compared to normal controls, the raised respiratory exchange ratio at peak exercise implying anaerobic metabolism due to limited oxygen delivery in heart failure and limited oxygen carrying capacity in anaemia. Minute ventilation (VE) was related linearly to minute CO2 production (VCO2) in all subjects (each r > 0.92) from all three groups. The slope of the VE/VCO2 relationship was normal in anaemia but steeper in heart failure, reflecting ventilation/perfusion mismatching in chronic heart failure.
对患有慢性肾性贫血或经治疗的慢性心力衰竭的患者匹配组以及正常对照组进行了比较，观察他们在最大强度跑步机运动时的心肺反应。与正常对照组相比，两个患者组的运动能力均同样降低，运动峰值时呼吸交换率升高，这意味着由于心力衰竭中氧输送受限以及贫血中氧携带能力受限而导致无氧代谢。在来自所有三组的所有受试者中（每组r>0.92），分钟通气量（VE）与分钟二氧化碳产生量（VCO2）呈线性相关。VE/VCO2关系的斜率在贫血患者中正常，但在心力衰竭患者中更陡，这反映了慢性心力衰竭中的通气/灌注不匹配。
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