Shields J A
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Retina. 1992;12(4):320-30. doi: 10.1097/00006982-199212040-00005.
For many years, enucleation has been the most common treatment of retinoblastoma. It generally has been done on the affected eye of children with unilateral disease and on the more severely affected eye in children with bilateral disease. In recent years, there has been a trend toward earlier diagnosis of retinoblastoma, and there have been refinements in conservative therapeutic methods, such as radiotherapy, photocoagulation, and cryotherapy. Consequently, it often is possible to salvage the affected eye and retain useful vision in many patients who would have undergone enucleation in the past. This article provides an update on the diagnosis and treatment of retinoblastoma, with emphasis on certain misconceptions related to the management of this tumor. New genetic aspects and their relationship to counseling are discussed briefly.
多年来，眼球摘除术一直是视网膜母细胞瘤最常见的治疗方法。通常对单侧患病儿童的患眼以及双侧患病儿童中病情较重的眼睛进行该手术。近年来，视网膜母细胞瘤的诊断有提早的趋势，并且保守治疗方法（如放射疗法、光凝疗法和冷冻疗法）也有所改进。因此，对于许多过去会接受眼球摘除术的患者，现在常常有可能挽救患眼并保留有用的视力。本文提供了视网膜母细胞瘤诊断和治疗的最新情况，重点关注与该肿瘤管理相关的某些误解。还简要讨论了新的遗传学方面及其与咨询的关系。
