埃塞俄比亚一家三级教学医院的儿科眼眶肿瘤特征、影像学和组织病理学一致性。

Pediatric Oculo-orbital Tumor Characteristics, Imaging and Histopathology Agreement in a Tertiary Level Teaching Hospital, Ethiopia.

机构信息

Department of Radiology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

Ethiop J Health Sci. 2022 Mar;32(2):313-320. doi: 10.4314/ejhs.v32i2.12.

DOI:10.4314/ejhs.v32i2.12

PMID:35693568

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9175222/

Abstract

BACKGROUND

Oculo-orbital tumors are frequently encountered pathologies and late diagnosis results in high morbidity and mortality in developing countries. This study aims to assess the computed tomography and magnetic resonance imaging patterns of pediatric oculo-orbital tumors with particular emphasis on retinoblastoma and compare agreement between imaging and histopathology diagnosis.

METHODS

A retrospective analysis of 101 pediatric patients with oculo-orbital lesions from February 2017 to January 2020 at Tikur Anbessa Specialized Hospital oncology center. Medical records were reviewed for clinical data, history, physical examination, pretreatment eye exam under anesthesia (EUA), computed tomography (CT) magnetic resonance imaging (MRI) and histopathology reports. The agreement between imaging and histopathology diagnosis was analyzed.

RESULTS

Malignant oculo-orbital tumors represented 97 (96.1%) cases. Age group 2-5 years had 56 (55.4%) cases of oculo-orbital tumors. Retinoblastoma accounted for 78 (77.2%) followed by rhabdomyosarcoma in 8 (7.9%) patients. The primary patient complaint was proptosis in 78 (77.2%) followed by leukocoria in 16 (15.8%). In 88 (89.7%) cases, there was agreement between imaging and histologic findings with 72 out of the 75 histopathology confirmed cases of retinoblastoma showing an agreement. Retinoblastoma patients presented at an advanced stage with orbital and intracranial extension.

CONCLUSIONS

In conclusion, patients with oculo-orbital tumors presented with advanced stage of disease. Excellent imaging and histopathology agreement was demonstrated.

摘要

背景

眼-眶部肿瘤是常见的病理类型，在发展中国家，由于诊断较晚，导致发病率和死亡率较高。本研究旨在评估小儿眼-眶部肿瘤的 CT 和 MRI 表现，特别强调视网膜母细胞瘤，并比较影像学与组织病理学诊断的一致性。

方法

回顾性分析 2017 年 2 月至 2020 年 1 月在提克里克·安巴塞斯专科医院肿瘤中心就诊的 101 例小儿眼-眶部病变患者的临床资料、病史、体格检查、麻醉下预处理眼部检查（EUA）、CT、MRI 和组织病理学报告。分析影像学与组织病理学诊断的一致性。

结果

恶性眼-眶部肿瘤占 97 例（96.1%）。2-5 岁年龄组有 56 例（55.4%）眼-眶部肿瘤。视网膜母细胞瘤占 78 例（77.2%），横纹肌肉瘤 8 例（7.9%）。主要的患者主诉是眼球突出，78 例（77.2%），其次是白瞳症，16 例（15.8%）。88 例（89.7%）患者的影像学与组织学发现一致，75 例经组织病理学证实的视网膜母细胞瘤中有 72 例存在一致性。视网膜母细胞瘤患者就诊时已处于晚期，伴有眼眶和颅内侵犯。