Ozono S, Takashima K, Yoshikawa M, Hirao Y, Okajima E
Department of Urology, Nara Medical University.
Hinyokika Kiyo. 1992 Nov;38(11):1285-92.
The current status and controversy of the treatment for renal cell carcinoma are reported. From 1980 to 1990, a total of 283 patients with renal cell carcinoma were treated in Nara Medical University and its affiliated hospitals. All patients were divided into two groups: M0 group (n = 217) and M1 group (n = 66). In addition, the M0 group patients were divided into two groups according to the followup study: M0-->M0 group (n = 194) and M0-->M1 group (n = 23). There was a significant difference between the survival of the M0 group and that of the M1 group (p < 0.001). A significant difference was also seen between the survival of M0-->M0 group and that of the M0-->M1 group (p < 0.001). The clinical and pathological factors which might be related to prognosis were analyzed. In the M1 group, high stage, high grade, non-surgical treatment for primary site and metastatic sites other than the lungs were found to be poor prognostic factors. In the M0-->M1 group, no prognostic factor was seen. These findings indicated that surgical treatment for the primary site in M1 patients should be performed. In addition, development of effective treatment for metastatic sites other than the lungs and effective postoperative adjuvant treatment would be necessary.
报告了肾细胞癌治疗的现状及争议。1980年至1990年，奈良医科大学及其附属医院共治疗了283例肾细胞癌患者。所有患者分为两组：M0组（n = 217）和M1组（n = 66）。此外，根据随访研究，M0组患者又分为两组：M0→M0组（n = 194）和M0→M1组（n = 23）。M0组和M1组的生存率存在显著差异（p < 0.001）。M0→M0组和M0→M1组的生存率也存在显著差异（p < 0.001）。分析了可能与预后相关的临床和病理因素。在M1组中，高分期、高分级、对原发部位及肺部以外转移部位进行非手术治疗被发现是预后不良的因素。在M0→M1组中，未发现预后因素。这些发现表明，应对M1患者的原发部位进行手术治疗。此外，有必要开发针对肺部以外转移部位的有效治疗方法以及有效的术后辅助治疗。
